Petroula Proitsi

This study uses Mendelian randomization to investigate ECS gene variants and their associations with dementia risk and biomarkers, finding some links but no strong causal evidence.

The paper identifies novel cross-trait associations using polytranscriptomic scores in Parkinson's disease and improves prediction models with multi-PTS integration.

This study assesses the association between APOE genetic variants and dementia risk in British South Asians using healthcare records and genotyping data.

This study uses Mendelian randomisation to identify causal metabolome-wide effects on psychiatric and neurodegenerative disorders, finding 85 significant associations and shared genetic variants.

This study uses polygenic and transcriptional risk scores to analyze psychiatric and cognitive symptoms in Parkinson's disease, finding distinct associations between genetic and transcriptional risks and symptom progression.

This study uses GWAS summary statistics to identify shared genetic loci across neuropsychiatric diseases and finds HLA region associations with potential shared causal variants.

This study investigates the genetic relationship between depression symptoms and Alzheimer's disease using GWAS and finds significant genetic correlations but no causal link, suggesting proxy cases may drive the overlap.

This study investigates genetic overlap and causality between blood plasma proteins and Alzheimer's Disease using polygenic risk scores and Mendelian Randomization, finding associations but no strong causal links.

This study uses Mendelian Randomization to investigate causal relationships between blood metabolites and Alzheimer's Disease, identifying several metabolites as potential causal factors.

This study identifies seven novel genetic loci for Alzheimer's disease using a large GWAS and highlights microglia and immune pathways as key contributors to disease pathology.

The paper integrates lipidomics and proteomics data to identify modules associated with Alzheimer's disease phenotypes and risk loci in immune and lipid pathways.

The paper shows that reducing CYFIP2 in mice leads to Alzheimer's disease-like features, suggesting CYFIP2 as a therapeutic target.

This study finds a genetic link between schizophrenia polygenic risk and psychotic symptoms, particularly delusions, in Alzheimer's disease through a meta-analysis of 11 cohort studies.

Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.

This study identifies 9 novel genetic loci and 215 potential causative genes associated with Alzheimer's disease risk through a large genome-wide association analysis.