Weihang Zhang

Gene2role embeds genes using multi-hop topological information from signed GRNs to identify topological changes across cell types and quantify module stability.

HyGAnno transfers cell type labels from scRNA-seq to scATAC-seq using a graph neural network, improving annotation accuracy and robustness.

This study identifies hysteresis genes in macrophage polarization and shows that AP-1 and CTCF regulate chromatin state changes during de/repolarization.