Systems BiologybioRxivPreprint
Oncogenic PIK3CA corrupts growth factor signaling specificity
Ralitsa Radostinova Madsen, Alix Le Marois, Oliwia N Mruk…·Bart Vanhaesebroeck
The paper uses single-cell analyses to show that oncogenic PIK3CAH1047R reduces IGF1 signaling specificity and enhances EGF responses, leading to increased phenotypic heterogeneity.
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