Tomas Geffner

Reward-guided inference-time search over the Proteína-Complexa sequence-structure codesign model yields validated binders across 127 targets, kinases and a free carbohydrate, with codesigned sequences outperforming ProteinMPNN redesign.

PINDER provides a benchmark dataset for evaluating protein-protein interaction docking models, revealing overestimation of performance on leaky test sets and showing improvements with interface-clustered training.