Shuyu Guo

GeneCompass is a cross-species foundation model pre-trained on single-cell transcriptomes from human and mouse, integrating biological knowledge to improve gene regulatory mechanism understanding and downstream tasks.

This study shows ATG6 interacts with NPR1, enhancing its nuclear accumulation and stability, which boosts Arabidopsis resistance to Pst DC3000/avrRps4.

This study identifies Kiaa1024L/Minar2 as essential for hearing by regulating cholesterol distribution in hair bundles, showing that its loss causes deafness in zebrafish.

This study identifies a Brazil nut effect-like mechanism driving spatial segregation of cell lineages in early mammalian embryos through cavity vibrations, without requiring chemical gradients.