Yewon Han

The paper predicts quaternary structures of viral proteins using AlphaFold2 and AlphaFold-Multimer, identifying new insights into vaccinology and protease targets.

The paper expands the AlphaFold Protein Structure Database to include proteome-scale quaternary structures, predicting 1.81M high-confidence protein complexes and revealing conserved structural clusters across domains of life.

The paper combines AlphaFold and ESMfold predictions to create a large structural dataset, identifies novel protein folds and domain combinations, and highlights the value of metagenomic data for structural diversity.