Jingi Yeo

The paper combines AlphaFold and ESMfold predictions to create a large structural dataset, identifies novel protein folds and domain combinations, and highlights the value of metagenomic data for structural diversity.

A Foldseek-based linear-time structural clustering groups 52 million AlphaFold DB representatives into 2.27 million non-singleton clusters; 31% lack known structural or domain annotation.