Charlotte R. K. Hoffman

The paper identifies PanDA, a bacterial defense system that uses a minimal diadenylate cyclase to detect phage evasion by sequestering c-di-AMP, leading to membrane permeabilization.

The paper identifies a novel antiphage system, Panoptes, that uses a minimal CRISPR polymerase to produce cyclic nucleotides and detects phage anti-defense proteins through effector binding and nucleotide depletion.