Alexander Maxwell Burroughs

Widespread Recruitment of ParA-like NTPases into Prokaryotic Immunity reveals a diversity of anti-selfish element strategies

The paper identifies ParA-like NTPases as key components in prokaryotic immunity, revealing diverse strategies to combat selfish genetic elements.

A novel RRM activity orchestrates ribosome homeostasis

40S subunit binding to a previously unrecognised RRM in LARP1 activates its TOP-binding HEAT repeats, licensing repression of ribosomal protein mRNA translation in human cells.

Cyclase-generated 3,5-cGMP activates PucsarTIR antiphage defense through a stepwise zig-zag aligned filament assembly

The paper identifies Pucsar, a bacterial antiphage system that uses 3,5-cGMP generated by a cyclase to activate TIR effectors through a stepwise filament assembly process.

EOLA1 functions in nucleotide salvage through deacetylating free N4-acetylcytidine

This study identifies EOLA1 as a deacetylase that recycles N4-acetylcytidine (acC) in nucleotide salvage, revealing a pathway for modified nucleotide recycling relevant to therapeutic RNA design.

A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins

The paper identifies a novel antiphage system, Panoptes, that uses a minimal CRISPR polymerase to produce cyclic nucleotides and detects phage anti-defense proteins through effector binding and nucleotide depletion.

The Lipocone Superfamily: A Unifying Theme In Metabolism Of Lipids, Peptidoglycan And Exopolysaccharides, Inter-Organismal Conflicts And Immunity

The paper identifies the Lipocone superfamily as a unifying theme in lipid metabolism, inter-organismal conflicts, and immunity across species.

The RNA helicase HrpA rescues collided ribosomes in E. coli

The paper shows that HrpA, an RNA helicase in E. coli, rescues stalled ribosomes by splitting collided ribosomes into subunits using ATP hydrolysis.

B. subtilis MutS2 splits stalled ribosomesinto subunits without mRNA cleavage

This study shows that MutS2 in B. subtilis splits stalled ribosomes into subunits without cleaving mRNA, differing from the E. coli SmrB mechanism.

Mechanism and evolutionary origins of Alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10

The paper investigates how Pirh2 and CRL2-KLHDC10 E3 ligases recognize Ala-tails, showing conserved binding sites and convergent evolution of their recognition mechanisms.

Ribosome collisions in bacteria promote ribosome rescue by triggering mRNA cleavage by SmrB

The paper identifies SmrB as a factor that cleaves mRNAs upstream of stalled ribosomes in bacteria, promoting ribosome rescue through ribosome collisions.

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.

The paper identifies widespread transcription initiation at microsatellites across species and develops deep learning models to predict STR-associated transcription and its impact on disease variants.

NONU-1 encodes a conserved endonuclease required for mRNA translation surveillance

The paper identifies NONU-1 as an endoribonuclease essential for translation surveillance pathways and shows its conservation across species.

Functional innovation in the evolution of the calcium-dependent system of the eukaryotic endoplasmic reticulum

The paper investigates the evolution of the calcium-dependent system in eukaryotes, identifying its origins and key innovations across species.

The unexpected provenance of components in eukaryotic nucleotide-excision-repair and kinetoplast DNA-dynamics from bacterial mobile elements

The paper identifies the bacterial origin of DNA repair and kinetoplast DNA components in eukaryotes through computational analysis of protein domains.