Molecular BiologybioRxivPreprint
Regulation of the Na-K-2Cl cotransporter NKCC2 by ubiquitylation
Louise Nyrup Odgaard, Agnes Thoroee, Olivier Staub…·Lena Lindtoft Rosenbæk
This study develops a mammalian cell model to investigate NKCC2 ubiquitylation, showing that K871 ubiquitylation regulates membrane localization and function, while Nedd4-2 affects total abundance but not trafficking.
DOI 10.64898/2026.05.07.723577