Jun Yang

This study shows DOX-induced cardiotoxicity spreads via paracrine signaling through extracellular vesicles, with plasma EV miRNA profiles indicating risk stratification and potential biomarkers for early detection.

This study shows substrate stiffness affects fibroblast EV size and composition through mechanotransduction pathways, with distinct roles for p53 and thioredoxin in different fibroblast types.

This study uses a hybrid in vivo model to show that the aged extracellular matrix promotes breast cancer progression, with LOX identified as a key driver.

This study creates age-mimetic breast cancer models to assess drug responses in young and aged microenvironments, identifying age-specific drug targets.

This study shows that normal fibroblasts near a breast tumor produce EVs that promote cancer progression, using 3D bioprinted stromal models.

The paper compares extracellular vesicles from young and aged patients and identifies age-related changes in cargo that correlate with cardiovascular disease.

This study identifies miRNA-124's role in cervical cancer by regulating CD45 alternative splicing and Th cell immune function through the GSK3-PSF-CD45 pathway.