Pınar Zorlutuna

Doxorubicin-induced Cardiotoxicity is Propagated by Paracrine Signaling through Small Extracellular Vesicles

This study shows DOX-induced cardiotoxicity spreads via paracrine signaling through extracellular vesicles, with plasma EV miRNA profiles indicating risk stratification and potential biomarkers for early detection.

Mitochondria Clearance Enables Macrophage-Driven Maturation of iPSC-Derived Cardiomyocyte Metabolism

This study shows that adding macrophages to cardiomyocytes improves their metabolic maturity through mitochondrial clearance and mitophagy.

3D Bioprinted Fat-Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

This paper develops a 3D bioprinted model of fat-myocardium to study how adipocyte hypertrophy contributes to atrial dysfunction in obesity and shows metformin improves electrophysiological function.

Substrate Stiffness Modulates Fibroblast Extracellular Vesicle Secretion via Mechanotransduction Pathways

This study shows substrate stiffness affects fibroblast EV size and composition through mechanotransduction pathways, with distinct roles for p53 and thioredoxin in different fibroblast types.

Hybrid In Vivo Breast Cancer Model Reveals Transcriptomic Insights into Cancer Progression with Age

This study uses a hybrid in vivo model to show that the aged extracellular matrix promotes breast cancer progression, with LOX identified as a key driver.

Instant fluorescence lifetime imaging microscopy reveals mechano-metabolic reprogramming of stromal cells in breast cancer peritumoral microenvironments

This study uses instant FLIM to show that mechanical compression of stromal cells in breast cancer models alters their metabolism, with distinct effects on fibroblasts and adipocytes, validated by transcriptomics and mitochondrial analysis.

Engineered Age-Mimetic Breast Cancer Models Reveal Differential Drug Responses in Young and Aged Microenvironments

This study creates age-mimetic breast cancer models to assess drug responses in young and aged microenvironments, identifying age-specific drug targets.

Investigating the impact of fibroblast proximity to a tumor on fibroblast extracellular vesicle production utilizing 3D bioprinted stromal models

This study shows that normal fibroblasts near a breast tumor produce EVs that promote cancer progression, using 3D bioprinted stromal models.

Comprehensive Multi-omics Mapping of Vesicle Cargo from Plasma or Novel Tissue Vesicles Reveals Pathological Changes in Cargo with Patient Age

The paper compares extracellular vesicles from young and aged patients and identifies age-related changes in cargo that correlate with cardiovascular disease.