Cell BiologyAmerican Journal of Physiology-Endocrinology and MetabolismPeer-reviewed
VPS41 deletion triggers progressive loss of insulin stores and downregulation of beta-cell identity
Belinda Yau, Yousun An, Mark Germanos…·Melkam Alamerew Kebede
This study shows that VPS41 deletion causes insulin degradation and loss of beta-cell identity in mice, with lysosomal inhibition rescuing insulin content.
DOI 10.1152/ajpendo.00389.2024