Bharath R. Takulapalli

This paper introduces a method to map epitopes at the single amino acid level by screening antibody drugs against a mutationally-scanned target protein library on a biosensor chip, identifying critical residues for binding.

The paper introduces a high-throughput proteomic platform called SPOC that enables real-time label-free screening of protein interactions with kinetic analysis capabilities.

This paper demonstrates a high-throughput method to produce and characterize thousands of single-chain antibodies on an SPR biosensor chip, providing detailed kinetic data to support antibody discovery and AI pipelines.