Author

Tyler Chickering

Alnylam Pharmaceuticals (United States)ORCID 0009-0006-9529-7258Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Adam B. Castoreno· 2 shared Ivan ZlateviD· 2 shared Kelly Wassarman· 2 shared Mark K. SchlegeliD· 2 shared Vasant JadhaviD· 2 shared Alexandria M. DoerfleriD· 1 shared Anna Bisbe· 1 shared Ayrea E. HurleyiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetics

Adam B. Castoreno

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2 papers

Recent·Most cited

GeneticsScience Translational MedicinePeer-reviewedFeb 12, 2025

In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene

Marco De Giorgi, So Hyun Park, Adam B. Castoreno…·William R. Lagor

This paper introduces a method to increase the proportion of correctly repaired hepatocytes in the liver through transient gene inhibition and transgene delivery, achieving a 25% increase in targeted cells and five-fold transgene expression.

8 citations

mouseCRISPR screen

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GenomicsNature CommunicationsPeer-reviewedApr 8, 2023

RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes

Megha P. Subramanian, James McIninch, Ivan Zlatev…·Vasant Jadhav

This paper develops an RNAi-based rheostat to dynamically control AAV-delivered transgene expression using siRNA or shRNA and REVERSIR technology for induction.

11 citations

experimental assay

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