William R. Lagor

This paper identifies BMP signaling as a driver of heterotopic ossification by promoting ciliogenesis and establishing a sensitized signaling hub that facilitates osteochondrogenic differentiation.

This paper introduces a method to increase the proportion of correctly repaired hepatocytes in the liver through transient gene inhibition and transgene delivery, achieving a 25% increase in targeted cells and five-fold transgene expression.

This paper maps the tissue tropism of ten AAV serotypes in mice after systemic delivery, identifying liver preference and unexpected transduction in adrenals, testes, and ovaries.

This paper introduces a novel gene therapy platform using covalently linked adenovirus-AAV complexes to improve co-infection efficiency and reduce AAV dose requirements.

This study shows that IFT20 is essential for early chondrogenesis during endochondral ossification by regulating FGF signaling and Sox9 expression.