Author

Adam B. Castoreno

Alnylam Pharmaceuticals (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:non-human primate· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Mark K. SchlegeliD· 3 shared Ivan ZlateviD· 2 shared Kelly Wassarman· 2 shared Tuyen M NguyeniD· 2 shared Tyler ChickeringiD· 2 shared Vasant JadhaviD· 2 shared Alexandria M. DoerfleriD· 1 shared Alissa A. CoffeyiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Mark K. SchlegelORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Prevention of prion disease symptoms in mice with deep PrP lowering

Juliana E Gentile, Jonathan E. Farley, Margaret N. Kelemen, Meredith A Mortberg, Taylor L Corridon, Vanessa Laversenne, Jessica R Bombardier, Carlos Umaña, Kendrick DeSouza-Lenz, Michael Howard, Kenia Guzman, Nathan Chan, Daniel A. Sprague, Alissa A. Coffey, Jordyn Trapilo, , Eric Vallabh Minikel

This study demonstrates that deep PrP lowering with a potent siRNA prevents prion disease symptoms in mice and extends survival in symptomatic animals.

bioRxiv · Oct 24, 2026 · PreprintNeuroscience

In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene

Marco De Giorgi, So Hyun Park, Adam B. Castoreno, Mingming Cao, Ayrea E. Hurley, Lavanya Saxena, Marcel A. Chuecos, Christopher J. Walkey, Alexandria M. Doerfler, Mia N. Furgurson, M. Cecilia Ljungberg, Kalyani R. Patel, Sarah Hyde, Tyler Chickering, Stephanie Lefebvre, , William R. Lagor

This paper introduces a method to increase the proportion of correctly repaired hepatocytes in the liver through transient gene inhibition and transgene delivery, achieving a 25% increase in targeted cells and five-fold transgene expression.

Science Translational Medicine · Feb 12, 2025Peer-reviewedGenetics

RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes

Megha P. Subramanian, James McIninch, Ivan Zlatev, Mark K. Schlegel, Charalambos Kaittanis, Tuyen M Nguyen, Saket Agarwal, Timothy Racie, Martha Arbaiza Alvarado, Kelly Wassarman, Thomas S. Collins, Tyler Chickering, Christopher R. Brown, Karyn Schmidt, Adam B. Castoreno, , Vasant Jadhav

This paper develops an RNAi-based rheostat to dynamically control AAV-delivered transgene expression using siRNA or shRNA and REVERSIR technology for induction.

Nature Communications · Apr 8, 2023Peer-reviewedGenomics