Morgan Wu

CAST enables spatial-to-spatial searching and matching of single-cell spatial omics data across technologies and conditions, identifying disease-associated pathways and translational efficiency variations.

The paper creates a high-resolution spatial atlas of the mouse CNS by combining in situ sequencing with scRNA-seq data to map cell types and gene expression across the brain and spinal cord.

The paper introduces SPIN, a method to mitigate autocorrelation in spatial transcriptomics by subsampling neighbors, improving existing methods and enabling joint analysis across datasets.