Shuchen Luo

The paper uses spatial omics to analyze translational dysregulation in Grin2a+/- mice, finding gene-specific translation reductions in neurons and non-neuronal cells linked to schizophrenia pathophysiology.

This paper develops Deep-STARmap and Deep-RIBOmap for 3D spatial transcriptomics and translatomics in thick tissue blocks, enabling analysis of gene expression and immune interactions in human skin cancer.

CAST enables spatial-to-spatial searching and matching of single-cell spatial omics data across technologies and conditions, identifying disease-associated pathways and translational efficiency variations.

The paper creates a high-resolution spatial atlas of the mouse CNS by combining in situ sequencing with scRNA-seq data to map cell types and gene expression across the brain and spinal cord.