Hu Zeng

This study develops CIRCmap to profile cell-surface and intracellular RNAs, identifies cancer-associated csRNAs, and demonstrates oligonucleotide-drug conjugates targeting these RNAs show broad antitumor activity.

CAST enables spatial-to-spatial searching and matching of single-cell spatial omics data across technologies and conditions, identifying disease-associated pathways and translational efficiency variations.

The paper introduces RIBOmap, a 3D in situ method to profile mRNA translation at single-cell and spatial resolutions, revealing translation dependencies on cell cycle and subcellular localization in brain tissue.

This paper introduces TEMPOmap, a method to profile subcellular RNA kinetics in single cells, revealing kinetic gene clusters with distinct functional roles.

The paper introduces STARmap PLUS to map single-cell transcriptional states and disease markers in AD mouse models, revealing spatial relationships between cell types and pathological features.