Author

Laura Deelen

Imperial College LondonORCID 0009-0007-2295-2554Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Marco TrizzinoiD· 3 shared Martina Demurtas· 3 shared Zoe H. MitchelliD· 3 shared Alia Hafiz Abbas Gasim· 1 shared Andria Koulle· 1 shared Beatriz Garcia Del Valle· 1 shared Emma van Domselaar· 1 shared Fiona LewisiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersDevelopmental Biology

Marco TrizzinoORCID

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4 papers

Recent·Most cited

Cell BiologyBasic Research in CardiologyPeer-reviewedAug 12, 2026

TGF-β Signalling Drives Chemotaxis of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Response to MI Stimulus

Laura Deelen, Kazuya Kobayashi, Gowtham Reddy Cheruku…·Ken Suzuki

This study shows hiPSC-CMs migrate toward MI tissue, driven by TGF-β signalling, and identifies TGF-β as a key mediator of this chemotactic response.

DOI 10.1007/s00395-026-01201-9

humanbulk RNA-seq

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Developmental BiologyDevelopmentPeer-reviewedNov 28, 2025

Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers

Martina Demurtas, Samantha M. Barnada, Emma van Domselaar…·Marco Trizzino

This study shows SALL4 recruits BAF to CNCC-specific enhancers for neural crest induction, and SALL4A is essential for this process.

2 citations

humanexperimental assay

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GenomicsbioRxivPreprintApr 4, 2025

Hominoid-specific transposable elements rewired the expression of neural crest migration genes

Laura Deelen, Zoe H. Mitchell, Martina Demurtas…·Marco Trizzino

The paper identifies hominoid-specific transposable elements that regulate neural crest migration genes, showing their role in craniofacial evolution.

1 citation

humanexperimental assay

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Developmental BiologybioRxivPreprintFeb 14, 2025

CHD3 regulates BMP signalling response during cranial neural crest cell specification

Zoe H. Mitchell, Joery den Hoed, Willemijn J. J. Claassen…·Marco Trizzino

This study shows CHD3 regulates BMP signaling during cranial neural crest cell specification by modulating chromatin accessibility and gene expression.

2 citations

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