MYC and HSF1 Cooperate to Drive PLK1 inhibitor Sensitivity in High Grade Serous Ovarian Cancer
Imade Imasuen, Matthew O’Malley, Haddie DeHart, Bobby Walker, Vrushabh Ulhaskumar, Pranav Jothirajah, Haimanti Ray, Lisa Michelle Landrum, Joe Ryan Delaney, Kenneth P. Nephew, Richard L. Carpenter
This study identifies HSF1 and MYC co-amplification in ovarian cancer and shows that targeting PLK1 is more effective in these cells, suggesting a potential precision medicine approach.
Cancer Research Communications · Jan 20, 2025Peer-reviewedCancer Biology