Richard L. Carpenter

Deep-learning-enabled multi-omics analyses for prediction of future metastasis in cancer

This paper introduces EmitGCL, a deep-learning framework that predicts future metastasis in cancer with high accuracy, identifies biomarkers, and validates therapeutic targets.

SUV39H1 Preserves Cancer Stem Cell Chromatin State and Properties in Glioblastoma

This paper shows SUV39H1 is critical for maintaining glioblastoma stem cell properties and progression, and targeting it enhances chemotherapy effectiveness.

MYC and HSF1 Cooperate to Drive PLK1 inhibitor Sensitivity in High Grade Serous Ovarian Cancer

This study identifies HSF1 and MYC co-amplification in ovarian cancer and shows that targeting PLK1 is more effective in these cells, suggesting a potential precision medicine approach.

HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5

This study shows HSF1 suppresses CD8+ T cell infiltration in breast tumors by reducing CCL5 expression, thereby preventing immune-mediated tumor destruction.