Wen Xu

High-PepBinder generates target-specific peptides using a pLM-guided diffusion model and a comprehensive dataset, producing peptides with favorable binding properties and sequence diversity.

This study introduces cycledesigner, a method combining RFdiffusion, ProteinMPNN, and HighFold to design cyclic peptide binders for specific targets, followed by scoring functions for screening.

NCPepFold predicts structures of non-canonical cyclic peptides with improved accuracy using multigranular representation and cyclization optimization.