ImmunologyFrontiers in ImmunologyPeer-reviewed
SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2
Chao Shi Niu, Tingting Liang, Yongchong Chen…·Jiuwei Cui
This study identifies that SARS-CoV-2 spike protein induces cytokine release syndrome by enhancing T cell production of IL-2, which drives inflammatory cytokine release through TLR4 and NF-κB activation.
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