Dongqing Sun

STRIDE deconvolves spatial transcriptomics data using single-cell RNA sequencing to estimate cell-type proportions and improve spatial gene and domain identification.

The paper characterizes the tumor microenvironment of early-stage lung adenocarcinoma, identifying tertiary lymphoid structures and CD8 T cell exclusion mediated by follicular regulatory T cells.

TISCH provides an interactive web resource for visualizing single-cell transcriptomic data of the tumor microenvironment across multiple cancer types.

This study constructs the transcriptional regulatory network of Saccharomyces cerevisiae and analyzes its spatial organization in a 3D genome model, finding an optimized structure adapted to functional requirements.