Author

Xiwei Cheng

Broad InstituteORCID 0009-0007-7493-346XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Charlie Huh· 1 shared Jihang Chen· 1 shared Jing‐Ke WengiD· 1 shared Pengkang Guo· 1 shared Seonghwan SeoiD· 1 shared Songlin Jiang· 1 shared Wengong JiniD· 1 shared Woo Youn KimiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperBioinformatics

Charlie Huh

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintAug 2, 2026

Elucidating enzyme-substrate specificity through co-folding foundation model

Xiwei Cheng, Seonghwan Seo, Charlie Huh…·Wengong Jin

This paper introduces Boltz2ESI, a framework predicting enzyme-substrate interactions using a foundation model, outperforming existing methods by capturing active-site plasticity and evolutionary context.

DOI 10.64898/2026.07.30.741672

protein structureprotein sequence

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