ImmunologybioRxivPreprint
Human caspase-4 and caspase-5 assemble into non-canonical inflammasomes in response to overlapping and distinct LPS structures
Ling Wu, Kimberly A. Wodzanowski, Stephanie M Schreiner…·Sunny Shin
This study shows human CASP4 and CASP5 form SMOCs in response to LPS structures that evade TLR4 and Casp11, revealing their distinct roles in sensing bacterial LPS and implications for sepsis therapy.