Jenna Muscat-Rivera

Human caspase-4 and caspase-5 assemble into non-canonical inflammasomes in response to overlapping and distinct LPS structures

This study shows human CASP4 and CASP5 form SMOCs in response to LPS structures that evade TLR4 and Casp11, revealing their distinct roles in sensing bacterial LPS and implications for sepsis therapy.

High-throughput in vivo screening using barcoded mRNA identifies lipid nanoparticles with extrahepatic tropism for cancer immunotherapy

Anionic lipids modulate mRNA-lipid nanoparticle immunogenicity and confer protection in a mouse model of multiple sclerosis

This study shows that anionic lipids in mRNA-LNPs can modulate immune responses, reducing inflammation and disease in a multiple sclerosis mouse model.

Modeling Fibrosis with MASH Patient Liver-Derived Organoids.

The paper develops a 3D MASH liver fibrosis model using patient-derived organoids and shows that YAP1 knockdown reduces fibrosis by inducing myofibroblast senescence.