Author

Igor Brodsky

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Cornelius Y. TaabazuingiD· 1 shared Daniel GrubaughiD· 1 shared Edward F. KreideriD· 1 shared Jenna Muscat-Rivera· 1 shared Jilian Melamed· 1 shared Justin SuiD· 1 shared Katharine A FoxiD· 1 shared Kimberly A. WodzanowskiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Cornelius Y. TaabazuingORCID

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1 paper

Recent·Most cited

Human caspase-4 and caspase-5 assemble into non-canonical inflammasomes in response to overlapping and distinct LPS structures

Ling Wu, Kimberly A. Wodzanowski, Stephanie M Schreiner, Klarissa I Diaz, Katharine A Fox, Justin Su, Michael Kegel, Srikar Yelamarthy, Jenna Muscat-Rivera, Daniel Grubaugh, Madhura Kulkarni, Mallory Evans, Ricardo O Carale, Matthew E. Sherman, Cornelius Y. Taabazuing, , Sunny Shin

This study shows human CASP4 and CASP5 form SMOCs in response to LPS structures that evade TLR4 and Casp11, revealing their distinct roles in sensing bacterial LPS and implications for sepsis therapy.

bioRxiv · Oct 13, 2026 · PreprintImmunology