Euan A. Stronach

CELLector selects relevant cancer cell lines based on patient genomic data to improve in vitro model relevance and bridge cell line screens to primary tumor sub-cohorts.

The paper shows that targeting tandem amplified regions in CRISPR-Cas9 screens reduces cellular fitness, while chromosomal duplications have minimal effects.

CRISPRcleanR reduces false positives in CRISPR-Cas9 screens by correcting gene-independent responses without assuming copy number status.