Hanna Najgebauer

CRISPR-enhanced assessment of variants of unknown significance nominates oncology therapeutic targets and drug repositioning opportunities

CRISPR-VUS identifies rare variants linked to gene dependency in cancer cell lines, prioritizing potential drivers and therapeutic targets through functional validation.

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn's Disease Pathogenesis.

The paper identifies molecular signatures of Crohn's disease using scRNA-seq data from terminal ileal biopsies, highlighting key cell types and pathways involved in disease pathogenesis.

An integrated landscape of protein expression in human cancer

This study compiles a proteomics resource for cancer cell lines and tumour samples, finding that protein abundance in cell lines often reflects tumours but fails to capture subtype-specific variations.

Integrated cross-study datasets of genetic dependencies in cancer

The paper integrates two large CRISPR-Cas9 screens to improve the detection of gene dependencies and cancer vulnerabilities by addressing biases and batch effects.

CELLector: Genomics Guided Selection of Cancer in vitro Models

CELLector selects relevant cancer cell lines based on patient genomic data to improve in vitro model relevance and bridge cell line screens to primary tumor sub-cohorts.

CardioClassifier: demonstrating the power of disease- and gene-specific computational decision support for clinical genome interpretation

CardioClassifier is a decision-support tool for inherited cardiac conditions that improves variant interpretation by integrating disease-specific annotations and case data.