Alex V. Carr

The paper develops metaSPLiT, a single-cell RNA sequencing method, to reveal sub-species functional specialization in the human gut microbiome.

This study identifies pathway partitioning as a mechanism for complete denitrification in microbial communities and shows how imbalances in substrate utilization can disrupt cooperativity and lead to nitrous oxide emissions.

The paper uses microbial community-scale metabolic models to predict C. difficile engraftment risk and assess probiotic therapy efficacy in the human gut.