Author

Andrea Grazzi

University of MilanORCID 0009-0007-9270-8362Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Chelsea M. BrowniD· 1 shared Maurizio SironiiD· 1 shared ‪Siewert J. MarrinkiD· 1 shared Stefano PieracciniiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBiophysics

Chelsea M. BrownORCID

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1 paper

Recent·Most cited

BiophysicsCommunications ChemistryPeer-reviewedAug 31, 2026

Ligand Binding Free Energy Landscapes at the Tubulin Colchicine Site from Coarse-Grained Metadynamics

Andrea Grazzi, Chelsea M. Brown, Maurizio Sironi…·Stefano Pieraccini

This study evaluates coarse-grained funnel metadynamics for modeling ligand binding at the tubulin colchicine site, showing improved statistical convergence and reasonable accuracy compared to all-atom simulations.

1 citation

protein structuredeep learning

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