Author

Stefano Pieraccini

University of MilanORCID 0000-0002-7672-0720Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Alice MaiocchiiD· 1 shared Andrea Enrico ProtaiD· 1 shared Andrea GrazziiD· 1 shared Anne‐Catherine AbeliD· 1 shared Chelsea M. BrowniD· 1 shared Daniele PassarellaiD· 1 shared Erica Elisa FerrandiiD· 1 shared Graziella CappellettiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Alice MaiocchiORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Ligand Binding Free Energy Landscapes at the Tubulin Colchicine Site from Coarse-Grained Metadynamics

Andrea Grazzi, Chelsea M. Brown, Maurizio Sironi, ‪Siewert J. Marrink, Stefano Pieraccini

This study evaluates coarse-grained funnel metadynamics for modeling ligand binding at the tubulin colchicine site, showing improved statistical convergence and reasonable accuracy compared to all-atom simulations.

Communications Chemistry · Aug 31, 2026Peer-reviewedBiophysics

Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras

Alice Maiocchi, Anne‐Catherine Abel, Milo Jarno Basellini, Helena Pérez‐Peña, Zlata Boiarska, Erica Elisa Ferrandi, Zuzanna Kozicka, Valerio Fasano, Stefano Pieraccini, Graziella Cappelletti, Michel Olivier Steinmetz, Daniele Passarella, Andrea Enrico Prota

This study designs and tests PROTACs targeting β-tubulin, showing two compounds effectively degrade tubulin in cells.

bioRxiv · May 22, 2025 · PreprintBiochemistry