Author

Tianhua Zhai

University of PennsylvaniaORCID 0009-0007-9712-9132Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:machine learning (classical)· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Charles ZhengiD· 2 shared Li SheniD· 2 shared Anyu PaniD· 1 shared Dokyoon KimiD· 1 shared Fangyuan ZhangiD· 1 shared Jonghyun LeeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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2 shared papersBioinformatics

Charles ZhengORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 20, 2026

Integrating Multisource Target Evidence with Machine-Learning Potency Prediction for Alzheimer's Disease Drug Discovery

Anyu Pan, Tianhua Zhai, Jonghyun Lee…·Li Shen

The paper develops a platform integrating multisource target evidence with machine learning for Alzheimer's drug discovery, improving potency prediction and model performance.

DOI 10.64898/2026.10.14.759026

humanmachine learning (classical)

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BioinformaticsbioRxivPreprintJul 14, 2026

Integrative single-nucleus multi-omics profiling identifies candidate regulators and signaling axes in Alzheimer's disease lipid-processing microglia

Charles Zheng, Tianhua Zhai, Fangyuan Zhang, Li Shen

The paper identifies candidate regulators and signaling axes in Alzheimer's disease lipid-processing microglia through multi-omics analysis across multiple cohorts.

DOI 10.64898/2026.07.10.737805

humanscRNA-seq

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