Author

Jan C Nelis

UNSW SydneyORCID 0009-0007-9758-7328Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Elia Mächler· 1 shared Jacob E. CorniD· 1 shared Mandy Y. Boontanrart· 1 shared Simone PontaiD· 1 shared Viviana G Preiano· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperGenetics

Elia Mächler

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1 paper

Recent·Most cited

GeneticseLifePeer-reviewedJun 2, 2023

Engineering of the Endogenous HBD promoter increases HbA2

Mandy Y. Boontanrart, Elia Mächler, Simone Ponta…·Jacob E. Corn

This study uses CRISPR-Cas9 to edit the endogenous {delta}-globin promoter to increase HbA2 expression in human erythroid cells, showing that multiple transcription factor elements are required for effective upregulation.

4 citations

humanCRISPR screen

𝕏 PostBluesky