Author

Ronan McHugh

Queen's University BelfastORCID 0009-0008-0003-7897Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

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Approach:experimental assay· 1

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Angeliki KaramitriiD· 1 shared Atsuro OishiiD· 1 shared Bernard MasriiD· 1 shared Erika CeconiD· 1 shared Hiroyuki H. OkamotoiD· 1 shared Irina G. TikhonovaiD· 1 shared Julie DamiD· 1 shared Kazuhiro KobayashiiD· 1 shared

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintNov 8, 2025

Structural basis and physiological significance of non-canonical Gs coupling to the prototypical Gi-coupled melatonin MT1 receptor

Atsuro Oishi, Hiroyuki H. Okamoto, Keisuke Ikegami…·Ralf Jockers

The paper shows MT1, a Gi-coupled receptor, can also couple to Gs proteins, activates the Gs/cAMP pathway under long-term melatonin exposure, and presents the first solved structure of a Gi-coupled receptor-Gs complex.

DOI 10.1101/2025.11.08.687348

experimental assay

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