Author

Hiroyuki H. Okamoto

Kyorin UniversityORCID 0000-0002-4655-2498Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Osamu NurekiiD· 2 shared Aika Iwama· 1 shared Akiko OgawaiD· 1 shared Angeliki KaramitriiD· 1 shared Atsuro OishiiD· 1 shared Bernard MasriiD· 1 shared Chisae NagiriiD· 1 shared Erika CeconiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Osamu NurekiORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintNov 8, 2025

Structural basis and physiological significance of non-canonical Gs coupling to the prototypical Gi-coupled melatonin MT1 receptor

Atsuro Oishi, Hiroyuki H. Okamoto, Keisuke Ikegami…·Ralf Jockers

The paper shows MT1, a Gi-coupled receptor, can also couple to Gs proteins, activates the Gs/cAMP pathway under long-term melatonin exposure, and presents the first solved structure of a Gi-coupled receptor-Gs complex.

DOI 10.1101/2025.11.08.687348

experimental assay

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BiophysicsNature CommunicationsPeer-reviewedNov 7, 2024

Structural insights into the agonist selectivity and structure-based engineering of the adenosine A3 receptor

Hidetaka S. Oshima, Akiko Ogawa, Fumiya K. Sano…·Osamu Nureki

The paper identifies a novel A3R-selective ligand and reveals structural insights into A3R activation, enabling structure-guided engineering of m6A-insensitive A3R for drug discovery.

15 citations

humanstructural biology

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