Keisuke Ikegami

The paper shows MT1, a Gi-coupled receptor, can also couple to Gs proteins, activates the Gs/cAMP pathway under long-term melatonin exposure, and presents the first solved structure of a Gi-coupled receptor-Gs complex.

The paper develops a mathematical framework explaining circadian intraocular pressure (IOP) rhythms through the additive interaction of glucocorticoid and norepinephrine signals, showing it accounts for species differences and age-related changes.

This study shows that weekly shifts in light-dark cycles cause internal desynchronization in the hepatic molecular clock and metabolic pathways in middle-aged mice.

This study identifies RHOB as a mediator of norepinephrine-induced intraocular pressure elevation in the trabecular meshwork, suggesting it as a potential therapeutic target for glaucoma.