Lukas Laufer

MethylBench benchmarks DNA methylation profiling methods across sequencing platforms, finding consistent DMC hotspots and highlighting platform-specific strengths and limitations.

ESMM improves epigenomic state annotation by integrating DNA methylation and chromatin marks, enhancing the detection of heterochromatic regions and regulatory element boundaries.

EpiSegMix improves chromatin state segmentation by using a flexible hidden Markov model with duration modeling, outperforming existing tools in predicting gene expression.