Jakob Admard

This study identifies genomic features, particularly copy-number alterations, that predict metastatic progression in melanoma and defines a six-gene signature associated with relapse.

MethylBench benchmarks DNA methylation profiling methods across sequencing platforms, finding consistent DMC hotspots and highlighting platform-specific strengths and limitations.

This study uses long-read RNA sequencing to analyze transcript diversity and regulation in human fibroblasts, induced pluripotent stem cells, and cortical neurons, revealing transcript-specific changes in disease-related genes.

This study uses microfluidic RNA-seq to analyze axonal transcriptomes from iPSC-derived neurons, revealing unique transcriptional features and highlighting the role of KIF1C in axonal health and neurodegeneration.

This study shows that overexpression of human alpha-synuclein in rats leads to gut microbiome dysbiosis, altered metabolites, and aging-related changes that can be modulated by antibiotics.

The paper identifies and compares the abundance of ATXN3 splice variants in blood and cerebellum of SCA3/MJD patients and controls, finding tissue-specific expression patterns of full-length ataxin-3 isoforms.

This study shows that enriched environments reduce inflammation markers in Parkinson's disease mice by altering gut bacteria.