Suyue Lyu

This paper designs de novo AAV vectors with unique serological profiles using a variational autoencoder, achieving transduction efficiency and nAb avoidance in human sera.

The paper introduces the Dayhoff Atlas, a resource with large protein sequence datasets and generative models to improve protein design and prediction.

The paper introduces a variational autoencoder for generating synthetic viral vector serotypes with reduced pre-existing immune response, validated through structural and dynamic analysis.