Michael Garton

Generative design of de novo AAV vectors with unique serological profiles

This paper designs de novo AAV vectors with unique serological profiles using a variational autoencoder, achieving transduction efficiency and nAb avoidance in human sera.

ARCHIVE: An Efficient Open-Ended DNA Recording Device Capable of Multiplexed Capture of Pol-II Transcribed Signals

The paper introduces ARCHIVE, a DNA recording device that efficiently captures RNA-polymerase II transcribed signals with improved temporal resolution compared to existing methods.

FAST-STEM: A human pluripotent stem cell engineering toolkit for rapid design-build-test-learn development of human cell-based therapeutic devices

FAST-STEM accelerates human pluripotent stem cell engineering by enabling rapid transgene integration and differentiation into multiple cell types.

Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation

This study systematically tests HMBS missense variants to determine their functional impact and distinguish pathogenic from benign variants.

ProteinVAE: Variational AutoEncoder forTranslational Protein Design

The paper introduces a variational autoencoder for generating synthetic viral vector serotypes with reduced pre-existing immune response, validated through structural and dynamic analysis.

A Flexible Transgene Integration Landing-Pad Toolkit in Human Induced Pluripotent Stem Cells Enables Facile Cellular Engineering, Gene Zygosity Control, and Parallel Transgene Integration

This paper introduces a toolkit for transgene integration in hiPSCs using a safe-harbour locus, enabling controlled transgene configurations and efficient cellular engineering.