Author

Allan D. Friesen

Texas Biomedical Research InstituteORCID 0009-0008-2723-3556Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Organism:non-human primate· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Vitaly V. GanusoviD· 2 shared Christian Dide-AgossouiD· 1 shared Gregory T. RobertsoniD· 1 shared Martin I. VoskuiliD· 1 shared Matthew J. Reichlen· 1 shared Max McGrathiD· 1 shared Nicholas D. WalteriD· 1 shared Ryan PetersoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

Vitaly V. GanusovORCID

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2 papers

Recent·Most cited

MicrobiologyMicrobiology SpectrumPeer-reviewedJun 15, 2026

Immortal genome assumption significantly underestimates replication and death rates of Mycobacterium tuberculosis in mice and monkeys

Allan D. Friesen, Vitaly V. Ganusov

The paper challenges the assumption that Mtb DNA decay rates reflect bacterial death rates, showing that Mtb replication and death rates are still significant even with slow DNA decay.

DOI 10.1128/spectrum.03020-25

mousenon-human primate

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MicrobiologybioRxivPreprintDec 18, 2025

Mind the gap: Understanding discordance between culture- and a non-culture-based measure of bacterial burden in murine tuberculosis treatment models

Samuel T. Tabor, Allan D. Friesen, Matthew J. Reichlen…·Nicholas D. Walter

This study evaluates the CFU-16S rRNA gap in tuberculosis treatment models, finding that the discrepancy is partially due to residual 16S rRNA from dead bacteria and potential transient viable but non-culturable populations.

2 citations

mousemetagenomics

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