Lotte Mayer

The paper shows how mimiviruses create a subcellular environment to overcome codon-tRNA mismatch by localizing viral mRNAs and proteins at the periphery of a viral factory.

This study uses smFISH and other techniques to visualize Mimivirus transcription and translation sites in Acanthamoeba host cells, showing transcription occurs at defined spots and translation occurs in a ring around them.