Author

David DeCoeur

University of Massachusetts AmherstORCID 0009-0008-4552-2343Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Min CheniD· 2 shared Bryant Wu· 1 shared Jianhan CheniD· 1 shared Joshua C. FosteriD· 1 shared Lan Nguyen· 1 shared Nguyen Ly· 1 shared Olgica MilenkovićiD· 1 shared Samantha Schultz· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

Min ChenORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintAug 29, 2026

Single-Molecule Nanopore Profiling of p53-TAD Conformational Dynamics, Interactions, and Inhibition

David DeCoeur, Samantha Schultz, Jianhan Chen, Min Chen

This study uses a nanopore platform to analyze the conformational dynamics and interactions of p53-TAD, showing how a mutation and a drug affect its structure and binding.

DOI 10.64898/2026.08.28.747917

humanexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintAug 29, 2026

Subtyping active-site inhibitor binding mode to Abl kinase using super-resolution nanopore tweezers.

Nguyen Ly, Yu-Hsiang Wang, Joshua C. Foster…·Min Chen

This paper introduces a nanopore tweezers platform to subtype Abl kinase inhibitors by resolving ionic current signatures, achieving high classification accuracy without structural determination.

DOI 10.64898/2026.08.27.747610

humanexperimental assay

𝕏 PostBluesky