Sonja Nykänen

The paper identifies hsa-miR-92a-3p as a regulator of cell-cycle and signaling programs during human extra-embryonic lineage commitment using single-cell and bulk RNA-seq data.

The paper shows that mechano-osmotic changes in pluripotent stem cells influence chromatin state and fate transitions by integrating mechanical and biochemical signals.

The paper integrates scRNA-seq data to identify metabolically quiescent 8CLCs resembling human 8-cell stage embryos and characterizes their gene expression networks.