Adib Keikhosravi

Re-establishment of TAD boundary organization during DNA replication

The paper identifies DNA replication machinery components as critical for TAD boundary re-establishment during DNA replication.

TAD boundaries and gene activity are uncoupled

The paper investigates the relationship between TAD boundaries and gene activity using single-cell imaging, finding they are largely uncoupled.

Orderly mitosis shapes interphase genome organization

The paper identifies molecular regulators of centromere distribution by screening nuclear proteins and shows that mitosis influences interphase genome organization.

OptoLoop: An optogenetic tool to probe the functional role of genome organization

OptoLoop enables light-induced manipulation of chromatin contacts to study genome organization's role in gene regulation, showing looping-mediated repression of TERT.

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells

The paper shows that mechano-osmotic changes in pluripotent stem cells influence chromatin state and fate transitions by integrating mechanical and biochemical signals.

Simulation and quantitative analysis of spatial centromere distributionpatterns

The paper develops a framework to quantitatively analyze spatial centromere distribution patterns using clustering metrics and modeling techniques, identifying Ripleys K Score as the most accurate metric.

HiTIPS: High-Throughput Image Processing Software for the Study of Nuclear Architecture and Gene Expression

HiTIPS provides a flexible, open-source platform for high-throughput image analysis in cell biology, supporting customization and integration of new algorithms for tasks like segmentation, tracking, and quantification.