Jordan F. Safer

The yEvo Mutation Browser helps students and researchers visualize and interpret genome sequencing data from experimental evolution studies of yeast.

This paper introduces a framework for comparing embedding spaces in molecular biology, demonstrating its utility in pre-filtering machine learning tasks and identifying differential patterns across embeddings.

PFES quantifies the protein context of missense variants, enabling mechanistically transparent interpretation and reclassification of variants of uncertain significance.

MAVISp provides a modular structural framework for analyzing protein variant effects, offering over eight million variants across 1000 proteins with curated data and a web server for accessibility.

The paper maps MAVE data to human reference sequences to improve variant functional assay utility for genomics applications.

The paper introduces the Genomics 2 Proteins Portal, which links genetic variants to protein sequences and structures to aid in understanding disease mechanisms and therapeutic design.